Sh3rf1 CLIA Kit for Rat(Rattus norvegicus) | EIAab.comSh3rf1 CLIA Kit for Rat(Rattus norvegicus)

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Sh3rf1 (Gene name),

E3 ubiquitin-protein ligase SH3RF1 (Protein name ), SH3R1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Sh3rf1(Posh;Sh3md2);

Protein name:

E3 ubiquitin-protein ligase SH3RF1;

Alternative:

SH3 domain-containing RING finger protein 1;Plenty of SH3s(Protein POSH);SH3 multiple domains protein 2;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with HERP1 (By similarity). Interacts with Rac; in a GTP-dependent manner. Interacts with MAP3K10 and MAP3K11. Interacts with MAPK8IP; this interaction leads to the PJAC complex (POSH-JIP or SH3RF1/MAPK8IP apoptotic complex) with a 1:1 ratio. Interacts with SIAH1. Probably part of a signaling complex that may contain SH3RF1, MAPK8IP, DLK1, MAP2K4, MAP2K7, MAPK8, MAPK9, AKT1 and AKT2.

Function:

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes such as UBE2D1 or UBE2N and then transfers it to substrates. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis.

Subcellular Location:

Cytoplasm perinuclear region Cell projection lamellipodium Golgi apparatus trans-Golgi network Co-localizes, with AKT2, in lamellipodia (By similarity). Co-localizes, with HERP1, in trans-Golgi network.

Protein Attributes:

Sequence length:

894

Sequence:

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894:

EAELELKEGD | IVFVHKKRED | GWFKGTLQRN | GKTGLFPGSF | VENI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10116.ENSRNOP00000013815

UniGene:

Rn.163325

Pfam:

PF00018

SMR:

Q71F54

KEGG:

rno:306417

String:

Q71F54

Pfam:

PF00097

Uniprot:

Q71F54

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ELISA Kit for Rat E3 ubiquitin-protein ligase SH3RF1

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E15485h

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96T

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ELISA Kit for Rat E3 ubiquitin-protein ligase SH3RF1

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E15485m

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96T

ELISA Kit for Rat E3 ubiquitin-protein ligase SH3RF1

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E15485b

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96T

ELISA Kit for Rat E3 ubiquitin-protein ligase SH3RF1

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E15485r

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96T

CLIA Kit for Rat E3 ubiquitin-protein ligase SH3RF1

Cat.:

U15485m

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96T

CLIA Kit for Rat E3 ubiquitin-protein ligase SH3RF1

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U15485b

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96T

CLIA Kit for Rat E3 ubiquitin-protein ligase SH3RF1

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U15485r

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96T

CLIA Kit for Rat E3 ubiquitin-protein ligase SH3RF1

Cat.:

U15485h

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96T

Polyclonal Antibody for Rat E3 ubiquitin-protein ligase SH3RF1

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P15485Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat E3 ubiquitin-protein ligase SH3RF1

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P15485Rb-h

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40ug/0.2ml

Polyclonal Antibody for Rat E3 ubiquitin-protein ligase SH3RF1

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P15485Rb-m

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40ug/0.2ml

Monoclonal Antibody for Rat E3 ubiquitin-protein ligase SH3RF1

Protein for Rat E3 ubiquitin-protein ligase SH3RF1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis."
Xu Z. , Kukekov N.V. , Greene L.A.
EMBO J.22:252-261(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH MAP3K10; MAP3K11; DLK1; MAP2K4; MAP2K7; MAPK8 AND MAPK9;UBIQUITINATION;FUNCTION
strain: New England Deaconess Hospital.
2.

"Siah1 interacts with the scaffold protein POSH to promote JNK activation and apoptosis."
Xu Z. , Sproul A. , Wang W. , Kukekov N. , Greene L.A.
J. Biol. Chem.281:303-312(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIAH1
3.

"Direct interaction of the molecular scaffolds POSH and JIP is required for apoptotic activation of JNKs."
Kukekov N.V. , Xu Z. , Greene L.A.
J. Biol. Chem.281:15517-15524(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAPK8IP;SUBCELLULAR LOCATION

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